Boston University Superfund Research Program

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Projects and Cores

Project 1: Prenatal Exposure to Tetrachloroethylene-Contaminated Drinking Water and the Risk of Birth Defects

Project Leader, Ann Aschengrau (Boston University School of Public Health)
Studying risk of birth defects in a population exposed to perchloroethylene (PCE, a peroxisome proliferator) in drinking water.


Project 2: Analyzing Patterns in Epidemiologic and Toxicologic Data

Project Leader,
Veronica Vieira (University of California, Irvine; Adjunct, Boston University School of Public Health),
Tom Webster (Boston University School of Public Health).
Developing improved methods for mapping epidemiologic and chemical mixture data on reproductive and developmental outcomes while adjusting for known risk factors.

Project 3: Environmental PPARĪ³ agonist-mediated toxicity in the developing immune system

Project Leader, Jennifer Schlezinger (Boston University School of Public Health)
Determining the molecular mechanism by which individual and complex mixtures of environmental chemicals impair the development of the mammalian immune system and accelerate bone aging.


Project 4: Mechanism and Impacts of Dioxin Resistance in Fish

Project Leader, Mark E. Hahn (Woods Hole Oceanographic Institution)
Co-investigator, Sibel I. Karchner (Woods Hole Oceanographic Institution)
Understanding mechanisms underlying differential sensitivity to the developmental toxicity of polychlorinated biphenyls (PCBs) that act through the aryl hydrocarbon receptor (AHR).


Project 5: Developmental Toxicity of non-Dioxin-like PCBs and Chemical Mixtures

Project Leader, John J. Stegeman (Woods Hole Oceanographic Institution)
Co-Investigator, Jared V. Goldstone (Woods Hole Oceanographic Institution)
A comprehensive study of ortho-PCB effects on development, and possible mechanisms using fish models.


Administrative Core

Project Leader, David M. Ozonoff (Boston University School of Public Health)
Facilitating collaborations between projects and cores.

Bioinformatics Core

Principal Core Leader, Stefano Monti (Boston University School of Medicine, Department of Medicine)
Co-Leader, Sandor Vajda (Boston University, Department of Biomedical Engineering)

Offering computational tools, expertise, and help to certain projects in modeling and analysis of microarray data.

Community Engagement Core

Project Leader, Madeleine Scammell (Boston University School of Public Health)
Seeking to establish collaborative projects with communities, health care providers, and investigators to address environmental health problems related to community exposure to hazardous waste; and to increase public awareness about environmental health problems and solutions.

Research Translation Core

Project Leader, Madeleine Scammell (Boston University School of Public Health)
Developing mechanisms to communicate with government agencies, to identify and transfer technology developed in the SRP to appropriate stakeholders, and to communicate research findings to broad audiences.

Training Core

Project Leader, Michael McClean (Boston University School of Public Health)
Facilitating student training, coursework, and distance learning for graduate students in these areas.