BUSBRP investigators Sandor Vajda (Bioinformatics Core) and John J. Stegeman (Project 6) have a new publication in the journal Biochemistry. In this e-Pub ahead of print the investigators used ensemble modeling to look at catalytic differences between related cytochromes P450.

BUSBRP investigator David J. Waxman (Project 3) also has a new publication in the Archives of Biochemistry and Biophysics. In this paper Sun et al. re-engineered cytochrome P450 2B11dH for increased metabolism of several substances.

• Prasad, Jahnavi C., Jared V. Goldstone, Carols J. Camacho, Sandor Vajda, and John J. Stegeman. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologs. Biochemistry. e-pub ahead of print: 2/15/2007

• Sun, Ling, Chong S. Chen, David J. Waxman, Hong Liu, James R. Halpert, and Santosh Kumar. 2007.  Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.  Arch biochem Biophys. 458(2):167-174