Two papers by BU SBRP researcher Dr. David Waxman were recently published. These papers, based on Dr. Waxman’s work in Project 3, are “The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARα” in the Journal of Pharmacy and Pharmacology and “Circulating free fatty acids are increased independently of PPARγ activity after administration of poloxamer 407 to mice” in the Canadian Journal of Physiology and Pharmacology.
Poloxamer 407 is a surface acting agent found in cosmetics, contact lens solution, toothpaste, and mouthwash. These papers provide insight into whether PPARs, a group of nuclear receptor proteins that act as transcription factors, have a role in the modulation of lipid levels in blood after administration of poloxamer 407.
Supported with funding from the
National Institute of Environmental Health Sciences' Superfund Research Program
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