BUSBRP investigators Sandor Vajda (Bioinformatics Core) and John J. Stegeman (Project 6) have a new publication in the journal Biochemistry. In this e-Pub ahead of print the investigators used ensemble modeling to look at catalytic differences between related cytochromes P450.

BUSBRP investigator David J. Waxman (Project 3) also has a new publication in the Archives of Biochemistry and Biophysics. In this paper Sun et al. re-engineered cytochrome P450 2B11dH for increased metabolism of several substances.

• Prasad, Jahnavi C., Jared V. Goldstone, Carols J. Camacho, Sandor Vajda, and John J. Stegeman. 2007. Ensemble modeling of substrate binding to cytochromes P450: Analysis of catalytic differences between CYP1A orthologs. Biochemistry. e-pub ahead of print: 2/15/2007

• Sun, Ling, Chong S. Chen, David J. Waxman, Hong Liu, James R. Halpert, and Santosh Kumar. 2007.  Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.  Arch biochem Biophys. 458(2):167-174

On Friday February 9, 2007, Dr. Pia Verkasalo MD PhD of the Finnish National Public Health Service will present "GIS in Environmental Epidemiological Studies: Experiences from Finland" at the BU School of Public Health. This seminar will begin at noon in the Talbot Building.

The UC San Diego SBRP has posted an online video archive of the SBRP Annual Conference held in December.  As part of Plenary Session 1: GIS and Environmental Monitoring, BU graduate student Lisa Gallagher presented the "Use of Water Distribution Model to Assess Exposure to Tetrachloroethylene-Contaminated Drinking Water." BU Program Director Dr. David Ozonoff also participated in a panel discussion during Plenary Session 4: From Lab Bench to Product.

Click here to view  the archive.

The BU Superfund Basic Research Program will be featuring comparative toxicologist Dr. Mark Hahn of the Woods Hole Oceanographic Institute in the current edition of the "Ask the Researcher" column. Dr. Hahn's research investigates mechanisms of adaptation and evolved resistance to PCBs in fish inhabiting a Superfund site in southeastern Massachusetts. Clickhere to ask him a question or to read his answers.